Fibrinogen and factor XIII
نویسندگان
چکیده
منابع مشابه
[Safety of plasma-derived factor concentrates: an example of pharmacovigilance with fibrinogen and factor XIII-concentrate].
Elaborate measures for donor selection and the production of clotting factor concentrates have led to a high safety standard of these products. A multimodal approach to eliminate unwanted contents has been established by strict screening of possible donors and various inactivation procedures within the production process. The systematic registration of adverse events shows very few allergic and...
متن کاملFree oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII
Background: Haemodilution and hypothermia induce coagulopathy separately, but their combined effect on coagulation has not been widely studied. Fibrinogen concentrate can correct dilutional coagulopathy and has an additional effect when combined with factor XIII concentrate. However, their effect on dilutional coagulopathy concomitant with hypothermia has not been studied previously. Free oscil...
متن کاملFree oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates
BACKGROUND Haemodilution and hypothermia induce coagulopathy separately, but their combined effect on coagulation has not been widely studied. Fibrinogen concentrate can correct dilutional coagulopathy and has an additional effect when combined with factor XIII concentrate. However, their effect on dilutional coagulopathy concomitant with hypothermia has not been studied previously. Free oscill...
متن کاملFibrinogen and factor XIII at the intersection of coagulation, fibrinolysis and inflammation.
Fibrinogen and factor XIII are two essential proteins that are involved directly in fibrin gel formation as the final step of a sequence of reactions triggered by a procoagulant stimulus. Haemostasis is the most obvious function of the resulting fibrin clot. Different variables affect the conversion of fibrinogen to fibrin as well as the mode of fibrin polymerisation and fibrin crosslinking, he...
متن کاملDose-response of fibrinogen and factor XIII concentrate for correcting albumin-induced coagulopathy
Objectives: Natural colloid albumin induces a lesser degree of dilutional coagulopathy than synthetic colloids. Fibrinogen concentrate has emerged as a promising strategy to treat coagulopathy, and factor XIII (FXIII) works synergistically with fibrinogen to correct coagulopathy following haemodilution with crystalloids. Objectives were to examine the ability of fibrinogen and FXIII concentrate...
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ژورنال
عنوان ژورنال: Current Opinion in Hematology
سال: 2018
ISSN: 1065-6251
DOI: 10.1097/moh.0000000000000445